Clozapine-induced Agranulocytosis and Use of G-csf
نویسندگان
چکیده
Use of clozapine is attended with the serious though rare risk of agranulocytosis. Clozapineinduced agranulocytosis is reversible with the use of cytokines like granulocyte-colony stimulating factor (G-CSF). Reports of the haematological complication of clozapine have not been forthcoming from India though it has been in use for nearly three years. This report is on an young patient who developed total absence of granulocytes during the 4th month of treatment who was successfully treated with G-CSF.
منابع مشابه
BRIEF REPORT Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte- Macrophage Colony-Stimulating Factor A Systematic Review
Purpose/Background: Clozapine is associated with hematological abnormalities, notably neutropenia, which may progress to agranulocytosis. Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been used to reduce the frequency and duration of clozapine-associated neutropenia. This review aims to explore the use, efficacy, and tolerabilit...
متن کاملG-CSF plasma levels in clozapine-induced neutropenia.
BACKGROUND Clinical reports emphasize the therapeutic usefulness of granulocyte colony-stimulating factor (G-CSF) in clozapine-induced granulocytopenia. Only sparse information exists, however, on the natural course of endogenous G-CSF plasma levels in this condition. METHODS We monitored G-CSF and white blood cell (WBC) counts in a 73-year-old patient who developed granulocytopenia while bei...
متن کاملInhibition of p38-mitogen-activated protein kinase may protect from clozapine-induced agranulocytosis.
Despite the clinical advantages of clozapine in the treatment of otherwise therapy-resistant schizophrenia, continuous administration results in neutropenia and life-threatening clozapine-induced agranulocytosis (CA) in about 2.2% and 0.8% of patients, respectively (Atkin et al. 1996). The aetiopathogenesis of these haematogeneous side effects is still uncertain, but there is increasing evidenc...
متن کاملکلوزاپین: انقلابی جدید در درمان شیزوفرنی
Clozapine is the first antipsycotic drug with a great efficacy. Thirty to fifty percent of treatment-resistant schizophrenics markedly improved with clozapine. Approximately, 25% of long-term patients, treated with clozapine, could be discharged. This improvement included negative as well as positive symptom areas. Clozapine produced no extrapyramidal side effects. Tardive dyskinesia, a major s...
متن کاملگزارش یک مورد آگرانولوسیتوز بدنبال مصرف کلوزاپین
Introduction : clozapine is the first effective antipsychotic drug with the least extra pyramidal side effects and more agranulocytosis than other standard neuroleptics. Granolocytopenia or agranulocytosis occurs in 1 to 2 percent of all patients treated with clozapine. agranulocytosis due to clozapine is a fatal disorder that requires immediate clinical intervention. Method : this paper re...
متن کامل